The Endocannabinoid System

BLOG: Why you should use Cannabinoids on your Skin

The Endocannabinoid System


In order to understand how CBD works, we first have to understand the body’s Endocannabinoid System (ECS). The NIH defines the ECS as, “a recently discovered signaling system comprising the cannabinoid CB1 and CB2 receptors, their intrinsic lipid ligands, endocannabinoids, and the associated enzymatic machinery.”1

The ECS is responsible for regulating many systems in the body, such as the limbic, metabolic, nociceptive, and immunologic functions. Endocannabinoids are natural chemical regulators in the body that interact with cannabinoid receptors and help maintain homeostasis. They seem to do this by detecting and regulating pain, mood, hunger, memory, and more.

If the ECS is affected, or the body is not producing enough endocannabinoids, these functions in the body may become unbalanced. And when the body is not producing or regulating endocannabinoids properly, ingesting natural cannabinoids or applying them topically can restore this balance. CBD differs from THC in the sense that THC mimics the natural cannabinoids in the body and binds with the cannabinoid receptors CB1 and CB2, which are found in abundance within the immune system, the gastrointestinal tract, and in the central and peripheral nervous systems. While THC binds to these receptors, CBD interacts with an enzyme called FAAH (fatty acid amide hydrolase).4

FAAH is responsible for pulling excess anandamide (a factor in homeostasis) out of circulation.

FAAH breaks down and removes natural endocannabinoids. CBD stops this breakdown and in turn increases the natural endocannabinoids available to the body. Because endo- cannabinoids have a balancing and healing effect on the body’s numerous systems and functions, CBD’s ability to increase the amount of endocannabinoids available to the body may create a bevy of therapeutic benefits.  CBD Skincare can aid many issues and also can  also be a great  preventive measure against developing problems later.


In 2012, Israeli scientists identified more than 1,200 genes affected by CBD: 600 gene transcripts were upregulated by CBD and 524 were downregulated. CBD has also been shown to regulate the expression of 491 genes, 165 in skin (4,18).CBD has been shown to activate both the cannabinoid and PPAR Gamma receptor in skin, which is probably responsible for its claimed skin benefits. Reported  benefits when using CBD Skincare include:

  • improved moisturization
  • improved skin barrier
  • skin soothing/anti-inflammatory
  • antipruritic
  • Acne/oil control
  • treating Psoriasis/Atopic Dermatitis


BLOG: Why you should use Cannabinoids on your Skin

The Endocannabinoid System


How Does CBD Affect Dogs?

Currently, there has been no formal study on how CBD affects dogs. What scientists do know is that cannabinoids interact with the endocannabinoid receptors located in the central and peripheral nervous systems, which help maintain balance in the body and keep it in a normal healthy state.

What Dog Health Problems Can CBD Oil Treat?

While there’s no definitive scientific data on using CBD to treat dogs, there’s anecdotal evidence from dog owners suggesting it can treat pain, especially neuropathic pain, as well as helping to control seizures.

According to Dr. Klein, CBD is also used because of its anti-inflammatory properties, cardiac benefits, anti-nausea effects, appetite stimulation, anti-anxiety impact, and for possible anti-cancer benefits, although there’s no conclusive data on this use.

The AKC Canine Health Foundation (CHF) is sponsoring a study through the Colorado State University’s College of Veterinary Medicine and Biomedical Sciences, that will evaluate the use of CBD in treatment-resistant epileptic dogs. The CHF hopes that this will be the first study to gain scientific data on the use of CBD in dogs with this condition.

CBD Products on the Market

If you and your veterinarian decide that you should try CBD as a treatment for your dog, there are a few things to keep in mind when purchasing CBD oil. Not all oils are the same; you’ll want high-quality CBD oil to have a better chance of it working.

  • Look for organic. If the CBD oil is not organic, it at least should not contain pesticides, fungicides, or solvents.
  • Don’t price shop. The higher the quality and purity, the higher the cost. You don’t want to go for a cheaper option that could have toxic substances such as pesticides, herbicides, or heavy metals. Make sure your CBD oil is free of additives.
  • Get the analysis. The manufacturer should provide a certificate that tells you the amount of CBD that is in the product. Many CBD products contain only small amounts of CBD. You’ll also want to make sure there is little or no THC in the product.
  • Buy CBD as a liquid. You can buy dog treats containing CBD, but the best form to administer is an oil or tincture. This way, you can adjust your dog’s dose drop by drop.Looking for the best quality vitamins and supplements for your pet? 

Try Nerogen Pet drops

Simple and easy Nerogen Pet Drops (Silver) are now available in a concentrated formula in a base of our *KOSHER *ORGANIC *OMRI *VEGAN *SUGAR-FREE *GLUTEN FREE OMEGA & VITAMIN RICH FIRST COLD PRESSED HEMP SEED OIL . Infused with 1mg of CBD per drop. 

Nerogen Silver for Pets is enhanced with the same Kosher, Omri Certified Organic, Vegan , Gluten free Hemp Seed oil that is in Our Human Grade formulas. No downgrading here. Your pets will enjoy the same high quality great taste and come running for their treat. 

Basic Dosing Rules For All Pets:

 0.25 mg to 0.5 mg CBD for every 1 lb bodyweight

We generally recommend between 0.25 mg (a Regular Dose) to 0.5 mg (a Strong Dose) of CBD per every 1 lb of bodyweight.

Example 1: I want to give my 40 lb dog a Regular Dose, I would multiply his weight by 0.25 to get 10mg of CBD (40 X 0.25 = 10).

Example 2: I want to give my 10 lb cat a Strong Dose, I would multiply his weight by 0.5 to get 4mg of CBD (10 lbs X 0.5 = 5mg).

REGULAR Dose: Daily health and wellness, boost immune function, old age, allergies, minor skin conditions, stimulate appetite, minor stress & anxiety, digestive issues & nausea, moderate arthritis & joint inflammation, minor aches, and pains.

STRONG Dose: Chronic pain, severe arthritis & joint inflammation, mobility issues, epileptic seizures, cancer-related symptoms, tumors, severe anxiety, extreme nausea, and vomiting.

Dosing Frequency: To control pain and inflammation, give every 8 hours or as needed. To control anxiety, give 30 minutes before the event (thunderstorm, fireworks, leaving the home, separation, traveling with pet). For all other uses give once to twice a day.

BLOG: Why you should use Cannabinoids on your Skin

BLOG: Why you should use Cannabinoids on your Skin

BLOG: Why you should use Cannabinoids on your Skin


It is becoming common knowledge that THC and CBD has anti-inflammatory properties to soothe sore muscles and relieve pain. This complex medicine does so much more. Cannabis has at least 80 different cannabinoids, a group of active compounds that give the plant its medical and psychoactive properties. Tetrahydrocannabinol (THC) might be the best-known cannabinoid, for creating the “high” effect, but non-psychoactive cannabidiol (CBD) tends to be the star in cannibis skincare. The benefits of CBD Skincare is  inevitable, and now there has been a new found benefit of cannabis in skincare. Skin ailments and conditions can be devastating, affecting the physical and mental well-being of those who have them.

With the increasing use of harsh chemicals in skin care products, people are searching for more organic and natural beauty products. And what better than CBD that has medicinal properties as well? Beauty products like face masks, day creams, and body lotions with CBD as its active ingredient are emerging rapidly. Whole plant CBD and hemp-derived CBD are natural anti-inflammatories, which makes them ideal for combatting skin ailments.

 Why Use CBD in Skincare?

It is well known that CBD was used as a curative herb thousands of years ago. It is now known as the magical herb having a myriad of health benefits. It is known to aid in the treatment of a wide range of skin diseases ranging from psoriasis, atopic dermatitis and acne to minimizing seizures, stress, and insomnia. 

Here are a few reasons as to why CBD works well in the skincare regime.

1. Healing Properties

CBD has therapeutic and anti-inflammation properties and can work better than vitamin C and A as an antioxidant. This can help to treat and soothe irritated skin, painful acne and stimulate cell regeneration for healthier, youthful look.

2. Produces Lipids

Research indicates that CBD has the ability to produce lipids, which are essential components of skin and play a crucial role in the skin’s barrier function. Thus, CBD helps in increasing the skin’s hydration and barrier function, and in regulating and treating the skin cells.

3.  Anti-Bacterial

Due to the presence of the terpenes in it, CBD has strong anti-bacterial, anti-inflammatory, antiseptic and sebum-reducing components. When applied to the affected area, it can work as both an anti-inflammatory and an antibiotic to heal and cure the infected area. 

4. Immunosuppressive

CBD, like other cannabinoids, has immunosuppressive properties, which means it can partially or completely suppress the immune response of an individual. This helps CBD to work on skin conditions from the inside out. This can help to treat severe skin diseases like Psoriasis. 

5. Ultraviolet Protection

Hemp oil, extracted from marijuana seeds, is loaded with fatty acids that address sun damage. UV rays are associated with a number of skin ailments like aging and cancer, so using CBD oil can ease dry skin and result in a healthier, more protected skin.

6. Stimulates The Endocannabinoid System

CBD stimulates activity in the body’s endocannabinoid system. The endocannabinoid system plays a key role in the regulation of sebum production. If your body is producing too much sebum, CBD can calm the sebaceous glands by regulating oil production. It can also provide much-needed balance to a deficient endocannabinoid system.

How To Incorporate CBD In Your Skincare?

1. CBD Oil

People have been using coconut oil and tea tree oil for centuries in their skin care routine but there’s an important ingredient to use- CBD oil. Apart for using CBD for anxiety, it can also be used directly as a night serum or can be added it to your scrubs and face masks for instant hydration and rejuvenation. 

2. CBD Infused Creams

Switch your regular cream with a CBD infused cream for replenished and supple skin. Many of these come with non-greasy and entirely plant-based formula and are specially designed to work with your natural pH to deliver the ultimate skin protection. 

3. Topicals

Topicals are the best method of application of CBD to give instant pain relief. Many people use these to treat aching feet and joints and to soothe cramped muscles. The anti-inflammatory properties are also perfect for prevention of wrinkles and acne. 

4. CBD Lip Balms

If you’re skeptical about using CBD beauty products, CBD infused lip balms are the best way to try out this trend. They work to hydrate and moisturize chapped and dry lips to give soft, supple lips and are available in fresh mesmerizing flavors.

5. CBD Cleansers

With CBD-infused cleansers, your daily skin care routine can benefit from the naturally nourishing and rejuvenating properties of CBD. These cleansers are sulfate free and gently washes away dirt and oil to leave your face smooth and youthful looking.

Using it can help to keep your pores clean and skin clarified.